#Problematic code: answer = input("Is it", guess, "?")
#input only accepts one argument, you are passing it 3. You need to use string
#formatting or concatenation to make it one argument:
answer = input("Is it {} ?".format(guess))
#You were confusing this with the print() function, which does indeed take more
#than one argument and will concatenate the values into one string for you.